Nicotinamide adenine dinucleotide (NAD+) fuels energy production, supports mitochondria, and helps cells repair themselves.1 As a coenzyme found in every living cell, NAD+ participates in hundreds of redox reactions that power life at its most fundamental level.2 These functions make NAD+ a focal point in functional and integrative medicine discussions.
However, most traditional NAD+ modalities have relied on intravenous administration, creating logistical barriers for some patients and providers. To address these barriers, Strive developed Flex-Dose NAD+ Tablets, designed for patient comfort, customized sublingual absorption, and simplified daily use.
How Flex-Dose Simplifies Personalized NAD+ Support
The Flex-Dose format reflects Strive Pharmacy’s broader mission to make personalization practical and accessible. We know not every patient is comfortable with needles—Flex-Dose NAD⁺ Tablets offer a convenient, sublingual option that may fit seamlessly into daily routines.
Each raspberry-marshmallow flavored tablet is scored for adjustable dosing, allowing providers to tailor NAD⁺ support based on tolerance, protocol progression, or combined compounding strategies. Sublingual absorption enables direct uptake through the oral mucosa, bypassing first-pass metabolism and supporting consistent delivery.
Flex-Dose tablets are specially designed to make dosing easier, allowing medication to fit your patient’s unique needs.
How to Split a Flex-Dose Tablet
For optimal precision when adjusting doses, patients can follow these simple steps:
- Place the tablet scored-side up on a hard, flat surface.
- Apply light, even pressure until the tablet splits cleanly along the score line.
- Take the prescribed portion as directed by their healthcare provider.
This straightforward design helps providers maintain precision while supporting patient comfort and adherence.
Potential Physiologic Roles of NAD+ Support
While research continues to expand, NAD+ is recognized for its multisystem influence across several physiologic domains:
- Energy and fatigue: Fuels mitochondrial ATP production, potentially influencing stamina and metabolism.1
- Neurocognitive performance: Serves as a cofactor for enzymes involved in neuronal signaling and DNA repair.3
- Cellular aging: Associated with sirtuin activity and maintenance of genomic stability.4
- Inflammatory balance: Linked to modulation of oxidative stress and immune pathways.5
Integrating Flex-Dose NAD+ into Clinical Practice
For providers already utilizing NAD+ in IV or injectable protocols, the Flex-Dose tablet offers a practical oral alternative.
The scored design makes it simple to titrate doses and build gradual patient adaptation, while the sublingual route enhances accessibility for those unable or unwilling to pursue infusions.
Flex-Dose NAD+ can also complement broader personalized protocols that include mitochondrial nutrients, B-vitamin cofactors, or antioxidant support.6
Personalized Care Starts with Flexible Options
In personalized medicine, flexibility is foundational. The ability to adjust dosing, delivery method, and frequency allows clinicians to match support with each patient’s biochemistry and lifestyle. The Flex-Dose design embodies that philosophy—combining pharmacologic precision with practical usability.
Everything we do at Strive is driven by a simple commitment: to constantly evaluate, improve, and push forward how we approach personalized patient care. Flex-Dose NAD+ Tablets are part of that evolution, making sophisticated support accessible in everyday life.
Key Takeaways for Providers
- NAD+ is vital for cell energy and repair.1
- Flex-Dose offers a flexible, sublingual tablet—no infusions needed.
- Scored design helps support gradual titration and patient comfort.
- Step-by-step instructions make home dosing straightforward.
- Reflects Strive’s commitment to personalized, precision-driven innovation in compounding.
Ready to take a deeper dive into NAD+ with Strive?
Join Strive’s clinical team for our next Strive Sessions webinar, where we’ll unpack the science, dosing strategies, and clinical applications of NAD+ support.
Click here to register and explore how Flex-Dose NAD+ tablets might fit into your personalized protocols and patient care plans.
References:
- Yusri K, Jose S, Vermeulen KS, Tan TCM, Sorrentino V. The role of NAD⁺ metabolism and its modulation of mitochondria in aging and disease. NPJ Metab Health Dis. 2025;3(1):26. doi:10.1038/s44324-025-00067-0. PMID: 40604314; PMCID: PMC12177089.
- Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD⁺ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-141. doi:10.1038/s41580-020-00313-x. PMID: 33353981; PMCID: PMC7963035.
- Lautrup S, Sinclair DA, Mattson MP, Fang EF. NAD⁺ in brain aging and neurodegenerative disorders. Cell Metab. 2019;30(4):630-655. doi:10.1016/j.cmet.2019.09.001. PMID: 31577933; PMCID: PMC6787556.
- Imai S, Guarente L. NAD⁺ and sirtuins in aging and disease. Trends Cell Biol. 2014;24(8):464-471. doi:10.1016/j.tcb.2014.04.002. PMID: 24786309; PMCID: PMC4112140.
- Poljsak B, Milisav I. NAD⁺ as the link between oxidative stress, inflammation, caloric restriction, exercise, DNA repair, longevity, and health span. Rejuvenation Res. 2016;19(5):406-415. doi:10.1089/rej.2015.1767. PMID: 26725653.
- Yusri K, Jose S, Vermeulen KS, Tan TCM, Sorrentino V. Role of NAD⁺ metabolism and its modulation of mitochondria in aging and disease. NPJ Metab Health Dis. 2025;3(1):26. doi:10.1038/s44324-025-00067-0. PMID: 40604314; PMCID: PMC12177089.
Disclaimers:
The information provided in this blog article is for informational and educational purposes only. Refer to the cited references for more information regarding the content presented. The information in this blog article is not intended as a substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking medical attention because of something you have read in this blog article. The creators of this content disclaim any liability for decisions made based on the information presented.
Consult your healthcare provider before starting any over-the-counter (OTC) products or prescription medications. Always seek the advice of your healthcare provider for any questions you may have regarding a medical condition. Certain medications may interact with your current prescription medications, medical conditions, or other supplements. Your healthcare provider can provide guidance tailored to your specific health needs.
Compounded medications are not approved by the FDA, and these statements have not been evaluated by the FDA.
