Conversations around growth hormone often raise important questions about physiologic signaling, regulation, and long-term system considerations. In our recent Strive Sessions webinar, Strive Pharmacy pharmacists Rob Khaler and Shalin Kochar explored the intended function of sermorelin and how endogenous growth hormone signaling differs from exogenous growth hormone administration.
Important Topics in Sermorelin Conversations
- How sermorelin supports endogenous growth hormone signaling and circadian rhythms
- Key considerations related to timing, formulations, and cycling
- How providers think about patient suitability, limitations, and overall patient management
Educational Insight for Sermorelin
Sermorelin Versus Exogenous Growth Hormone
Sermorelin is described in the literature as a GHRH analog intended to support the pituitary’s endogenous release of growth hormone in an episodic fashion that aligns with circadian rhythms rather than a bolus administration of growth hormone. The distinction is central to realizing the gains of growth hormone while avoiding potential unwanted effects of exogenous administration; the timing, patterns, and levels may be exerted within physiologic norms without disrupting feedback loops and adjacent hormonal systems.
Timing, Cycling, and Expectations
Conversations with patients should emphasize bedtime administration, cycling use for 5 days on and 2 days off, and use on an empty stomach. This helps to optimize potential benefit by minimizing downregulation of receptors and align growth hormone biology with circadian rhythms. Providers should set realistic expectations that accrue with continued use over months in the context of other drug interventions and lifestyle modifications.
Available formulations
Compounded as an injectable, nasal spray and buccal troche to suit a variety of preferences.
Sermorelin Cautions
Sermorelin should be avoided in pregnancy or breastfeeding as there is insufficient data to recommend use in these subpopulations. Do not use in patients with active cancers or tumors.
Watch the Sermorelin Strive Sessions Webinar Replay
This is just a snapshot of the breakdown available in Strive Sessions. This on-demand Strive Sessions webinar expands on the educational nuance and practical considerations, and it’s ready to go whenever you are:
Interested in a deeper dive into sermorelin? Tap here to read our full blog.
Disclaimer:
Compounded medications are specially prepared for individual patient needs and, as such, have not been reviewed or approved by the U.S. Food and Drug Administration (FDA). The statements in this article have not been evaluated by the FDA.
