The image shown is for illustrative purposes only and does not represent the actual appearance of your specific compounded medication.
NAD+
NAD+ is a vital coenzyme that supports energy production, cellular metabolism, and DNA repair. As levels decline with age, supplementation may help boost energy, support healthy aging, and enhance the body’s natural repair processes.
Nicotinamide Adenine Dinucleotide (NAD+)
Suggested Directions:
Subcutaneous or Intramuscular Injection (NAD+ 200 mg/mL):
- Inject 10 units (0.1 mL) three times weekly for 1 week, increase by 10 units (0.1 mL) weekly to a maximum dose of 50 units (0.5 mL) three times weekly.
- Gradually increase dose as tolerated.
Intravenous Infusion (NAD+ 200 mg/mL):
- Dilute 250-500 mg (1.25-2.5 mL) of NAD+ in 500-1,000 mL of IV fluid such as NS or LR.
- Infuse a SLOW drip rate over 2-4 hours for first time users. Rate can be determined based on a person's tolerance.
- Doses can be titrated up to 1,000 mg after multiple uses.
IMPORTANT INFORMATION ABOUT COMPOUNDED MEDICATIONS
This medication has been compounded (custom-prepared) by a pharmacy. Compounded medications are specially prepared for individual patient needs based on a valid prescription from a prescribing healthcare practitioner and, as such, are not reviewed or approved by the U.S. Food and Drug Administration (FDA) for safety or efficacy. Compounded drugs are intended for patients whose prescriber has determined their medical needs are not met by an available FDA-approved drug. These statements have not been evaluated by the FDA.
This compounded preparation:
- Has not been approved by the FDA
- Has not undergone FDA review for safety, effectiveness, or quality
- Is prepared specifically for you based on your prescriber's order
- Individual outcomes may vary
Dosing is determined by the prescribing provider based on patient-specific factors. Always follow your healthcare provider's instructions. Compounded medications are not subject to FDA approval and lack the same safety and efficacy data as FDA-approved commercial medications. This medication should be prescribed and monitored by a licensed healthcare professional familiar with the condition being addressed and the specific applications of the medication.
This compounded medication is only available when the commercially available product is unavailable or when a prescriber determines that there is a clinically significant difference for the patient.
Medicine Information
- Slowing cognitive decline
- Reducing fatigue and boosting energy levels
- Anti-inflammatory and anti-aging properties
- Supports mitochondrial energy production
- May help in neurodegenerative diseases providing neuroprotective benefit
Potential Side Effects
- Headache
- Nausea
- Dizziness
- Injection site reaction (with injection/infusion)
- Nasal irritation (spray)
- Muscle tightening or cramping
Warning
Increased levels of NAD+ can enhance glycolysis, potentially providing cancer cells with energy for rapid proliferation. Caution is advised, especially for individuals with a history of or susceptibility to cancer. Consultation with a healthcare professional is necessary before using NAD+ therapies.
NAD+ functions primarily as a carrier of electrons in redox reactions, which is crucial for energy production in cells. It plays a key role in metabolic pathways such as glycolysis, the citric acid cycle, and oxidative phosphorylation, while also maintaining cellular function and promoting repair processes.
IMPORTANT INFORMATION ABOUT COMPOUNDED MEDICATIONS
This medication has been compounded (custom-prepared) by a pharmacy. Compounded medications are specially prepared for individual patient needs based on a valid prescription from a prescribing healthcare practitioner and, as such, are not reviewed or approved by the U.S. Food and Drug Administration (FDA) for safety or efficacy. Compounded drugs are intended for patients whose prescriber has determined their medical needs are not met by an available FDA-approved drug. These statements have not been evaluated by the FDA.
This compounded preparation:
- Has not been approved by the FDA
- Has not undergone FDA review for safety, effectiveness, or quality
- Is prepared specifically for you based on your prescriber's order
- Individual outcomes may vary
Dosing is determined by the prescribing provider based on patient-specific factors. Always follow your healthcare provider's instructions. Compounded medications are not subject to FDA approval and lack the same safety and efficacy data as FDA-approved commercial medications. This medication should be prescribed and monitored by a licensed healthcare professional familiar with the condition being addressed and the specific applications of the medication.
1 . Conlon NJ. The Role of NAD+ in Regenerative Medicine. Plast Reconstr Surg. 2022 Oct 1;150(4 Suppl ):41S-48S. doi: 10.1097/PRS.0000000000009673. Epub 2021 Sep 28. PMID: 36170435; PMCID: PMC9512238.
2 . Braidy N, Berg J, Clement J, Khorshidi F, Poljak A, Jayasena T, Grant R, Sachdev P. Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes. Antioxid Redox Signal. 2019 Jan 10;30(2):251-294. doi: 10.1089/ars.2017.7269. Epub 2018 May 11. PMID: 29634344; PMCID: PMC6277084.
3. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141. doi: 10.1038/s41580-020-00313-x. Epub 2020 Dec 22. PMID: 33353981; PMCID: PMC7963035.
4. Campbell JM. Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts. Nutrients. 2022 Aug
7;14(15):3231. doi: 10.3390/nu14153231. PMID: 35956406; PMCID: PMC9370773.
5. Braidy N, Villalva MD, van Eeden S. Sobriety and Satiety: Is NAD+ the Answer? Antioxidants (Basel). 2020 May 14;9(5):425. doi: 10.3390/
antiox9050425. PMID: 32423100; PMCID: PMC7278809.
6 . San-Millán I. The Key Role of Mitochondrial Function in Health and Disease. Antioxidants. 2023; 12(4):782. https://doi.org/10.3390/antiox12040782.
Q: What is NAD+?
A: NAD+ is a crucial coenzyme involved in various metabolic processes, particularly energy production.
Q: How does NAD+ benefit health?
A: Potential benefits include improved brain function, reduced fatigue, enhanced metabolism, and possible neuroprotective effects.
Q: What are the side effects of NAD+ therapy?
A: Possible side effects can include headache, nausea, dizziness, and localized reactions at the injection site. Transient muscle tightness or cramping may occur as a side effect of NAD+ injection administration.
Always consult healthcare professionals for personalized medical advice.
