Vasoactive Intestinal Peptide (VIP)

STARTING AT

Per mL

Vasoactive Intestinal Peptide (VIP) is a naturally occurring 28 amino acid peptide renowned for its broad physiological roles such as vasodilation, anti-inflammatory activities, and the regulation of endocrine and exocrine systems. It is primarily used to help manage Chronic Inflammatory Response Syndrome.

STARTING AT

Per mL

ACTIVE INGREDIENTS
Vasoactive Intestinal Peptide
A peptide that is present in various tissues, including the gut, pancreas, central nervous system, and peripheral nervous system.
HOW TO USE
Suggested use
Administer 1 spray (50 mcg) four times daily alternating nostrils for the first month. May increase to 2 sprays (100 mcg) four times daily alternating nostrils for the second month.
DISCLAIMER
This compounded medication is only available when the commercially available product is unavailable or when a prescriber determines that there is a clinically significant difference for the patient.

Medicine Information

Potential Benefits

Help regulate inflammatory and autoimmune disorders by suppressing pro-inflammatory factors
Supports nerve regeneration in grey matter nuclear atrophy (as seen in CIRS)
May decrease neuroinflammation and encourage neuroplasticity in neurodegenerative diseases such as Alzheimer's and Parkinson's disease
Enhances airway relaxation and oxygenation
Relaxes intestinal smooth muscle and stimulate luminal secretion of water and electrolytes; may assist in improving motility.
Normalize estrogen and testosterone levels
Transiently improves insulin sensitivity and stimulates glucose-dependent insulin secretion
Promotes proliferation of pancreatic islet β-cells

Treatment Protocol

Legal

Storage Instructions

Warnings

Possible Side Effects

Headache, dizziness, stomach discomfort, and flushing
Hypotension

Manufacturer Info

How It Works

Vasoactive intestinal peptide (VIP) mediates its effects primarily through VPAC1 and VPAC2 receptors, which belong to the class B G protein-coupled receptor (GPCR) family. VIP initiates an enzymatic cascade leading to the activation of cAMP Response Element-Binding protein (CREB), influencing gene expression and various cellular responses. The activation of these pathways leads to smooth muscle relaxation, neuroprotection, vasodilation, enhanced glucose-dependent insulin secretion, reduced pro-inflammatory cytokines , and increased anti-inflammatory cytokines.

F.A.Q

References

Hou X, Yang D, Yang G, Li M, Zhang J, Zhang J, Zhang Y, Liu Y. Therapeutic potential of vasoactive intestinal peptide and its receptor VPAC2 in type 2 diabetes. Front Endocrinol (Lausanne). 2022 Sep 20;13:984198. doi: 10.3389/fendo.2022.984198. PMID: 36204104; PMCID: PMC9531956.

Shoemaker RC, Katz D, Ackerley M, et al. Intranasal VIP safely restores volume to multiple grey matter nuclei in patients with CIRS. Internal Medicine Review 3 (2017): Issue 4. pg 1-14.

Smalley SG, Barrow PA, Foster N. Immunomodulation of innate immune responses by vasoactive intestinal peptide (VIP): its therapeutic potential in inflammatory disease. Clin Exp Immunol. 2009 Aug;157(2):225-34. doi: 10.1111/j.1365-2249.2009.03956.x. PMID: 19604262; PMCID: PMC2730848.

Vu JP, Larauche M, Flores M, Luong L, Norris J, Oh S, Liang LJ, Waschek J, Pisegna JR, Germano PM. Regulation of Appetite, Body Composition, and Metabolic Hormones by Vasoactive Intestinal Polypeptide (VIP). J Mol Neurosci. 2015 Jun;56(2):377-87. doi: 10.1007/s12031-015-0556-z. Epub 2015 Apr 23. PMID: 25904310; PMCID: PMC4458420.