Glutathione

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Glutathione is a vital antioxidant found in nearly all human cells, essential for reducing oxidative stress and supporting immune function, liver detoxification, and inflammation control.

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ACTIVE INGREDIENTS
L-Glutathione (Reduced)
The active, antioxidant form of glutathione—an amino acid-derived compound that helps protect cells from damage caused by free radicals and toxins.
HOW TO USE
Suggested Dose
Glutathione 200 mg/mL Injectable Solution
IM/SC: Inject 200 mg (1 mL) intramuscularly (IM) or subcutaneously (SC) one to two times weekly OR Inject 100mg (0.5 mL) IM or SC every other day.
IV: Infuse 500 mg in normal saline or sterile water weekly. Dose may be increased slowly and given up to twice weekly depending on condition and desired results.
Consistent infusions may require additional cofactors to replenish nutrients depleted by glutathione.
Glutathione is relatively unstable and therefore should be used immediately or refrigerated for later use to ensure maximal potency and efficiency.
DISCLAIMER
This compounded medication is only available when the commercially available product is unavailable or when a prescriber determines that there is a clinically significant difference for the patient.

Medicine Information

Potential Benefits

Glutathione may support a range of conditions where endogenous levels are depleted due to high oxidative stress, systemic inflammation, or immune dysregulation. In addition, it plays an independent role in liver detoxification by aiding the elimination of harmful substances.

Alzheimer’s Disease and Parkinson’s Disease

Cardiovascular Disease

Chronic Fatigue Syndrome

COPD and Asthma

Decreased Hyperpigmentation & Improved Overall Skin Health

Depression and anxiety disorders

Diabetes

Inflammatory Bowel Disease

Liver Disease/Liver Detoxification of Harmful Chemicals

Multiple Sclerosis

Neuropathy

Rheumatoid Arthritis

Schizophrenia/Bipolar Disorders

Treament Protocol

Legal

Storage Instructions

Warnings

Individuals with pre-existing kidney disease should avoid high dose glutathione.
Avoid in pregnant or breastfeeding individuals due to a lack of safety data.
Excessive glutathione supplementation may impair immune signaling.
Glutathione may exert a limited effect in patients already on a medication regimen that harnesses anti-inflammatory pathways, such as ketamine in treatment-resistant depression.

Manufacturer Info

How It Works

Glutathione functions primarily as a potent intracellular antioxidant, neutralizing free radicals and reactive oxygen species (ROS) through its sulfur-containing thiol group. By donating electrons, it helps stabilize these reactive molecules and prevent oxidative damage to cells. It also plays a key role in detoxification by binding to toxins, making them more water-soluble and easier for the body to excrete. Additionally, glutathione supports immune function by aiding in the activation and regulation of immune cells, contributing to a balanced immune response. It helps maintain cellular integrity by modulating oxidative stress, assisting in protein repair, and influencing inflammatory pathways—ultimately promoting overall cellular homeostasis.

F.A.Q

References

Eshkevari, Ladan, et al. “Efficacy of addition of the anti-inflammatory, IV glutathione to standard ketamine IV therapy in major depressive disorder.” Psychiatry Research 337 (2024): 115949.

Bell CJM, Mehta M, Mirza L, Young AH, Beck K. Glutathione alterations in depression: a meta-analysis and systematic review of proton magnetic resonance spectroscopy studies. Psychopharmacology (Berl). 2024 Dec 21. doi: 10.1007/s00213-024-06735-1. Epub ahead of print. PMID:39708105.

Bounous, G., and J. Molson. “Competition for glutathione precursors between the immune system and the skeletal muscle: pathogenesis of chronic fatigue syndrome.” Medical hypotheses 53.4 (1999): 347-349.

Dean OM, van den Buuse M, Bush AI, Copolov DL, Ng F, Dodd S, Berk M. A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice. Curr Med Chem. 2009;16(23):2965-76. doi: 10.2174/092986709788803060. PMID: 19689277.

Fitzpatrick AM, Jones DP, Brown LA. Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2012 Jul 15;17(2):375-408. doi: 10.1089/ars.2011.4198. Epub 2012 Mar 9. PMID: 22304503; PMCID: PMC3353819.

Kaplowitz N. The importance and regulation of hepatic glutathione. Yale J Biol Med. 1981 Nov-Dec;54(6):497-502. PMID: 7342494; PMCID:PMC2596047.

Ueno, Yuki, et al. “Dietary glutathione protects rats from diabetic nephropathy and neuropathy.” The Journal of nutrition 132.5 (2002): 897-900.

Bravenboer B, Kappelle AC, Hamers FP, van Buren T, Erkelens DW, Gispen WH. Potential use of glutathione for the prevention and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat. Diabetologia. 1992 Sep;35(9):813-7. doi: 10.1007/BF00399926. PMID: 1397775.

Tredici G, Cavaletti G, Petruccioli MG, Fabbrica D, Tedeschi M, Venturino P. Low-dose glutathione administration in the prevention of cisplatin-induced peripheral neuropathy in rats. Neurotoxicology. 1994 Fall;15