Gonadorelin

Men: stimulate intratesticular testosterone production

• Increase spermatogenesis and preserve fertility
• Increase or maintain testicular volume.
• May exhibit fewer estrogenic side effects than hCG
• Enhances libido
• Higher energy levels and improved mood from increased testosterone

Women

• Induces ovulation in women who experience irregular ovulation and menstrual cycles due to insufficient GnRH
• Helps in normalizing menstrual cycles in women with irregular periods
• Restore the natural balance of reproductive hormones for overall reproductive health
• May improve sleep patterns by restoring hormonal balance

Potential side effects

• Headaches
• Nausea
• Abdominal pain
• Flushing
• Injection site reactions: such as pain, swelling, or redness

Note

Some medication regimens may require cycling or breaks to support your body’s natural hormone production and reduce the risk of side effects. Always consult your provider for personalized guidance before making any changes to your medication plan.

Stimulates the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary gland. In women, these hormones regulate ovulation and menstrual systems. In men, these hormones increase testosterone production, especially levels of intratesticular testosterone..

Q. How does gonadorelin compare to hCG?

A. Patients on testosterone who wish to stem or reverse testicular shrinkage may use either gonadorelin or low-dose hCG. Gonadorelin may come with fewer estrogenic effects compared to hCG and is generally considered the drug of choice in younger patients with fertility aspirations.

Q. How does gonadorelin affect semen?

A. Gonadorelin enhances semen production by increasing total expressible volume. It does appear to impact sperm quality.²

Ramasamy, Ranjith; Armstrong, Joseph M; Lipshultz, Larry I. Preserving fertility in the hypogonadal patient: an update. Asian Journal of Andrology 17(2):p 197-200, Mar–Apr 2015. | DOI: 10.4103/1008-682X.142772

Júnior, Jurandir Joaquim Bernardes, Robie Allan Bombardelli, and Alex Pires de Oliveira Nuñer. "Gonadorelin increases semen production and does not affect its quality in Leporinus obtusidens." Animal Reproduction Science 185 (2017): 154-160.