TRT Support
Hormone Therapy
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Capsule
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Oral
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Progesterone
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Progesterone is a natural hormone primarily produced in the ovaries and, to a lesser extent, in the adrenal glands. It is crucial for regulating the menstrual cycle, supporting pregnancy, and counterbalancing the effects of estrogen in the body.
ACTIVE INGREDIENTS
Micronized Progesterone
- Peanut-free compounded product
HOW TO USE
Progesterone Capsule
Dosing should be determined based on labs and clinical indication. Capsules are typically taken at night to avoid daytime drowsiness.
Progesterone Cream
Apply a small amount to clean, dry skin on the shoulders, upper arms, or inner thighs once daily, usually in the morning. Avoid applying to areas where clothes will rub.
Progesterone Troches
Place one troche in the buccal cavity (between the gum and cheek) and let it dissolve completely. Follow your healthcare provider's instructions regarding dosage.
DISCLAIMER
This compounded medication is only available when the commercially available product is unavailable or when a prescriber determines that there is a clinically significant difference for the patient.
Medicine Information
Potential Benefits
- Regulation of menstrual cycle
- Menopause symptom relief
- Prevention of endometrial hyperplasia
- Anti-inflammatory and immune-modulating effects
- Support pregnancy
Treament Protocol
When considering progesterone therapy, it's important to tailor the approach to the patient's clinical condition, route of administration, dosing goals, and potential risk factors. Here are key treatment considerations:
- Cyclic vs continuous dosing
- Timing: Progesterone given as an oral capsule will aid in sleep maintenance.
- Patient-specific factors: age, menopausal status, reproductive goals, and personal/family history should be considered when selecting dosing regimen
Legal
Storage Instructions
Warnings
Potential Side Effects
- Drowsiness or fatigue (especially with oral formulations)
- Headache
- Bloating or abdominal discomfort
- Breast tenderness
- Mood swings or irritability
- Acne or oily skin (rare, more common in high doses)
- Commercial progesterone capsules often contain peanut oil, which may pose a risk for patients with allergies. Compounded progesterone offers an allergen-free alternative and should be specifically requested for patients with known sensitivities. Be sure to document any allergies on the prescription to ensure the appropriate formulation is dispensed.
Manufacturer Info
How It Works
Progesterone exerts its effects by binding to intracellular progesterone receptors, which then act as transcription factors to regulate gene expression in target tissues like the uterus, brain, and breast. This leads to changes such as endometrial maturation, reduced uterine contractility, and modulation of mood and immune response.
Oral progesterone is absorbed through the gut and metabolized by the liver, producing neuroactive metabolites like allopregnanolone. These cross the blood-brain barrier and act on GABA-A receptors, helping to promote relaxation and improve sleep—especially in those with hormone-related sleep issues.
F.A.Q
Q: Who can take progesterone?
A: Men and women can take progesterone as part of their hormone replacement regimen. Despite being traditionally viewed as a female hormone, progesterone at lower doses in males serves several important functions.
Q: Why is progesterone used in HRT?
A: Progesterone is used in combination with estrogen in HRT to protect the uterus. It is also may be used to improve sleep.
Q: What is the difference between bioidentical progesterone and synthetic progestins?
A: Bioidentical progesterone (micronized progesterone) is chemically identical to what your body produces and is generally better tolerated. Synthetic progestins (medroxyprogesterone acetate) may have a higher risk of side effects and long-term health risks.
Q: What is the best time to take progesterone - day or night?
A: Oral progesterone capsules are often taken at night to help promote sleep.
References
Progesterone. (2025). In Lexi-Drugs. UpToDate Lexidrug. UpToDate Inc. Retrieved June 3, 2025, from https://online.lexi.com
Spark MJ, Willis J. Systematic review of progesterone use by midlife and menopausal women. Maturitas. 2012 Jul;72(3):192-202. doi: 10.1016/j.maturitas.2012.03.015. Epub 2012 Apr 25. PMID: 22541358.
Nagy B, Szekeres-Barthó J, Kovács GL, Sulyok E, Farkas B, Várnagy Á, Vértes V, Kovács K, Bódis J. Key to Life: Physiological Role and Clinical Implications of Progesterone. Int J Mol Sci. 2021 Oct 13;22(20):11039. doi: 10.3390/ijms222011039. PMID: 34681696; PMCID: PMC8538505.
