Elevate-T

Promotes systemic and intratesticular endogenous testosterone in hypogonadal men. DHEA and pregnenolone serve as hormone precursors. But DHEA may complement testosterone for body composition goals, and both DHEA and pregnenolone for mood and cognition support.^1,2,4-7

• Potential for muscle mass and strength
• Aids in libido and energy levels
• Supports mood and cognition
• Helps preserve sperm count and fertility in men with fertility aspirations.
• Compared to exogenous testosterone, enclomiphene does not induce testicular atrophy.

Potential Side Effects^2-4

• Decreased libido
• Decreased energy levels
• Headache
• Nausea
• Estrogenic side effects such as gynecomastia, bloating or mood swings (less incidence compared to clomiphene)

Handling Requirements

• Keep away from children and pets

Enclomiphene is a selective estrogen receptor modulator (SERM). It is the isomer of clomiphene primarily responsible for the studied pharmacological effects, whereas zuclomiphene is the isomer believed to be associated with unwanted effects. Enclomiphene antagonizes estrogen in the hypothalamic-pituitary-gonadal axis to support Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). LH helps stimulate the Leydig cells to produce testosterone. Intratesticular testosterone supports spermatogenesis and also confers broader systemic testosterone pharmacology. FSH acts on the Sertoli cells of the testes, and in concert with LH, modulates sperm health. FSH is instrumental in the functionality of spermatogenesis, sperm maturation, and sperm quality.^1,2 DHEA, pregnenolone and zinc play a supporting role in testosterone synthesis.

IMPORTANT INFORMATION ABOUT COMPOUNDED MEDICATIONS

This medication has been compounded (custom-prepared) by a pharmacy. Compounded medications are specially prepared for individual patient needs based on a valid prescription from a prescribing healthcare practitioner and, as such, are not reviewed or approved by the U.S. Food and Drug Administration (FDA) for safety or efficacy. Compounded drugs are intended for patients whose prescriber has determined their medical needs are not met by an available FDA-approved drug. These statements have not been evaluated by the FDA.

This compounded preparation:

• Has not been approved by the FDA
• Has not undergone FDA review for safety, effectiveness, or quality
• Is prepared specifically for you based on your prescriber's order
• Individual outcomes may vary

Dosing is determined by the prescribing provider based on patient-specific factors. Always follow your healthcare provider's instructions. Compounded medications are not subject to FDA approval and lack the same safety and efficacy data as FDA-approved commercial medications. This medication should be prescribed and monitored by a licensed healthcare professional familiar with the condition being addressed and the specific applications of the medication.

IMPORTANT INFORMATION ABOUT COMPOUNDED MEDICATIONS
This medication has been compounded (custom-prepared) by a pharmacy. Compounded medications are specially prepared for individual patient needs based on a valid prescription and, as such, are not reviewed or approved by the U.S. Food and Drug Administration (FDA) for safety or efficacy. These statements have not been evaluated by the FDA.

This compounded preparation:
- Has not been approved by the FDA
- Has not undergone FDA review for safety, effectiveness, or quality
- Is prepared specifically for you based on your prescriber's order
- Individual outcomes may vary

Dosing is determined by the prescribing provider based on patient-specific factors. Always follow your healthcare provider's instructions. Compounded medications are not subject to FDA approval and lack the same safety and efficacy data as FDA-approved commercial medications. This medication should be prescribed and monitored by a licensed healthcare professional familiar with the condition being addressed and the specific applications of the medication.

1. Wiehle R, Cunningham GR, Pitteloud N, Wike J, Hsu K, Fontenot GK, Rosner M, Dwyer A, Podolski J. Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics. BJU Int. 2013 Jul 12;112(8):1188–200. doi: 10.1111/ bju.12363. Epub ahead of print. PMID: 23875626; PMCID: PMC4155868.
2. Saffati G, Kassab J, Rendon DO, Hinojosa-Gonzalez DE, Kronstedt S, Lipshultz LI, Khera M. Safety and efficacy of enclomiphene and clomiphene for hypogonadal men. Translational Andrology and Urology. 2024 Sep 30;13(9):1984-90.
3. Gupta MC, Khanna J. Clomiphene citrate: the changing landscape. Int J Basic Clin Pharmacol. 2018 Aug;7(8):1437-43.
4. Thomas J, Suarez Arbelaez MC, Narasimman M, et al. Efficacy of Clomiphene Citrate Versus Enclomiphene Citrate for Male Infertility Treatment: A Retrospective Study. Cureus. 2023;15(7):e41476. Published 2023 Jul 6. doi:10.7759/cureus.41476
5. Walther A, Seuffert J. Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set? World J Mens Health. 2020 Apr;38(2):178-190. doi: 10.5534/wjmh.190006. Epub 2019 Jun 4. PMID: 31190486; PMCID: PMC7076306.
6. Murugan S, Jakka P, Namani S, Mujumdar V, Radhakrishnan G. The neurosteroid pregnenolone promotes degradation of key proteins in the innate immune signaling to suppress inflammation. J Biol Chem. 2019 Mar 22;294(12):4596-4607. doi: 10.1074/jbc.RA118.005543. Epub 2019 Jan 15. PMID: 30647133; PMCID: PMC6433066.
7. Te L, Liu J, Ma J, Wang S. Correlation between serum zinc and testosterone: A systematic review. J Trace Elem Med Biol. 2023 Mar;76:127124. doi: 10.1016/j.jtemb.2022.127124. Epub 2022 Dec 23. PMID: 36577241.
8. Hohl A, Chavez MP, Pasqualotto E, Ferreira ROM, Sande-Lee SV, Ronsoni MF. Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials. Arch Endocrinol Metab. 2025;69(5):e250093. Published 2025 Oct 9. doi:10.20945/2359-4292-2025-0093
9. Fontenot GK, Wiehle RD, Podolski JS. Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice. BJU Int. 2016;117(2):344-350. doi:10.1111/bju.13244
10. Mauvais-Jarvis, Franck, and Sarah H. Lindsey. "Metabolic benefits afforded by estradiol and testosterone in both sexes: clinical considerations." The Journal of Clinical Investigation 134.17 (2024).
11. Finkelstein, Joel S., et al. "Gonadal steroids and body composition, strength, and sexual function in men." New England Journal of Medicine 369.11 (2013): 1011-1022.

Q. I am already on Elevate-T to support testosterone while preserving fertility. Can I use it with any other meds that will support fertility goals even further?

A. Yes. Low dose gonadorelin or hCG are often used in men on exogenous testosterone to help safeguard from fertility concerns. But keep in mind that gonadorelin and hCG can also be used to further support fertility in men on Elevate-T.

Q. I want to get the most out of Elevate-T. Will I get a stronger effect using it on all 7 days of a week instead of only 5 days out of 7?

A. Elevate-T may exert more favorable advantages if cycled 5 days out of 7. The key active ingredient in this formulation is enclomiphene which opposes estrogen receptors in the hypothalamus to encourage a cascade of downstream effects. However, whenever a biological signal is present for prolonged periods, it may potentially downregulate the receptors it acts upon. Cycling the Elevate-T is a best-practice to ensure the medication does not weaken over time.

Q. I understand Elevate-T is an option in men with fertility aspirations, but are there any other reasons why one would opt for Elevate-T?

A. Whilst testosterone replacement can be executed responsibly within physiologic norms, many patients are nevertheless leery of direct hormonal administration. Testosterone is sometimes associated with adverse effects such as elevated hematocrit, increased prostate specific antigen (PSA) and worse serum lipid levels. The enclomiphene in Elevate-T has not been associated with significant serum biomarker alterations. Moreover, Elevate-T tends to maintain testosterone within physiologic norms, which limits side effects such as acne or hirsutism linked to supraphysiologic testosterone levels.⁸

Q. You also offer a Test Booster which seems comparable to Elevate-T. Which one is better for me?

A. The SERM used in Test Booster is clomiphene, which is a racemic mixture of both enclomiphene and zuclomiphene. Purified enclomiphene is the sole SERM in Elevate-T. Whereas enclomiphene exerts desirable pharmacological responses, zuclomiphene is responsible for certain estrogenic side effects. As such, enclomiphene exhibits a more favorable adverse effect profile than clomiphene.^2-4 Furthermore, literature suggests that when zuclomiphene was administered in isolation in preclinical models, it adversely affected testicular histology such as Leydig cells, seminal vesicles and epididymis.⁹ This is echoed in the finding that compared to clomiphene, enclomiphene not only encourages a robust gonadotropin release, but is also associated with an improvement in total motile sperm cell counts in published evaluations.⁴ The choice of whether to use Test Booster or Elevate-T would also factor in patient preference.

Q. Other than tracking sex steroid hormones and related biomarkers such as SHBG, is it necessary to monitor any other labs with Elevate-T?

A. Since Elevate-T carries minimal potential unwanted effects compared to exogenous regimens, monitoring blood parameters would be contingent upon individual clinical history, but it is not an absolute mandate.

Q. My estrogen labs have risen in addition to my testosterone on this med. Should I be concerned?

A. A modest change in estrogens along with testosterone is a normal physiological response. As part of normal physiology, your body will convert some testosterone to estrogen. Enclomiphene (in Elevate-T) generally limits testrogenic unwanted effects among similar compounds. It is a misconception that estrogen and testosterone necessarily antagonize each other. When testosterone and estrogen increase in tandem, it may support an array of tissue responses and libido parameters. By itself, estrogen has a weak anabolic effect. But it does play a role in muscle regulation, sensitizing it to exercise stimuli and testosterone’s actions. The balance in estrogen may also support cardiovascular and nervous system wellness, maintain bone mineral density, and aid mood and cognition parameters.^10,11