Progesterone
Hormone Therapy
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Capsule
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Oral
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Elevate T
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DHEA/Enclomiphene Citrate/Pregnenolone/Zinc Sulfate
Elevate-T is a synergistic combination of enclomiphene with hormonal precursors and Zinc intended to promote endogenous testosterone production in hypogonadal men. Enclomiphene is the active isomer of clomiphene responsible for its desirable pharmacological effects while minimizing estrogenic side effects.
ACTIVE INGREDIENTS
Enclomiphene Citrate
- Selective Estrogen Receptor Modulator (SERM)
- 100% enclomiphene (trans-isomer of clomiphene)
DHEA (dehyroepiandrosterone)
- DHEA is produced naturally by the adrenal gland and helps produce other hormones
Pregnenolone
- Precursor hormone that supports the production of testosterone
Zinc Sulfate Monohydrate
- An essential nutrient supporting in testosterone sysnthesis
HOW TO USE
Suggested dose
Elevate T (DHEA/Enclomiphene Citrate/Pregnenolone/Zinc Sulfate) 25/25/25/25mg
Take 1 capsule by mouth daily for 5 days on 2 days off, or as directed by your healthcare provider.
DISCLAIMER
This compounded medication is only available when the commercially available product is unavailable or when a prescriber determines that there is a clinically significant difference for the patient.
Medicine Information
Potential Benefits
Increase endogenous systemic and intratesticular testosterone in hypogonadal men. Testosterone may support improved muscle mass and strength, libido, energy level and mood and cognition.
- Fewer unwanted estrogenic effects such as mood changes, gynecomastia, and fluid gain compared with clomiphene
- Preserve sperm count and fertility in men with fertility aspirations.
- Compared to exogenous testosterone, enclomiphene will not lead to testicular atrophy.
Treament Protocol
Legal
Storage Instructions
Warnings
Potential Side Effects
- Headache and nausea
- Nausea
- Visual disturbances (blurring)
- Estrogenic side effects such as gynecomastia, bloating or mood swings (lesser risk with Elevate-T as compared to clomiphene)
Manufacturer Info
How It Works
Enclomiphene is a Selective Estrogen Receptor Modulator (SERM). It is an isomer of clomiphene primarily responsible for desired pharmacological effects, whereas zuclomiphene is the isomer responsible for side effects. Enclomiphene antagonizes estrogen in the hypothalamic-pituitary-gonadal axis to induce Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). LH stimulates the Leydig cells to produce testosterone. The resulting high intratesticular testosterone supports spermatogeneis. FSH works synergistically with LH, acting on the Sertoli cells of the testes and play a role in spermatogenesis, sperm maturation, and sperm quality. DHEA, pregnenolone and zinc play a supporting role in testosterone synthesis.
F.A.Q
References
Wiehle R, Cunningham GR, Pitteloud N, Wike J, Hsu K, Fontenot GK, Rosner M, Dwyer A, Podolski J. Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics. BJU Int. 2013 Jul 12;112(8):1188–200. doi: 10.1111/ bju.12363. Epub ahead of print. PMID: 23875626; PMCID: PMC4155868.
Saffati G, Kassab J, Rendon DO, Hinojosa-Gonzalez DE, Kronstedt S, Lipshultz LI, et al. MP47-02 ENCLOMIPHENE VS. CLOMIPHENE: SAFETY AND TESTOSTERONE LEVELS IN HYPOGONADAL MEN. Journal of Urology [Internet]. 2024 May 1 [cited 2025 Feb 18];211(5S):e762. Available from: https:// doi.org/10.1097/01.JU.0001008880.11564.10.02
Walther A, Seuffert J. Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set? World J Mens Health. 2020 Apr;38(2):178-190. doi: 10.5534/wjmh.190006. Epub 2019 Jun 4. PMID: 31190486; PMCID: PMC7076306.
Te L, Liu J, Ma J, Wang S. Correlation between serum zinc and testosterone: A systematic review. J Trace Elem Med Biol. 2023 Mar;76:127124. doi: 10.1016/j.jtemb.2022.127124. Epub 2022 Dec 23. PMID: 36577241.
