Olympus +

Potential benefits

• Support libido^{1, 5, 7}
• Help with sexual receptivity^{1, 5}
• Relaxes smooth muscle and promotes blood flow⁶
• Supports rapid onset of arousal^{1, 4, 5}
• Aids in erection quality and sensitivity¹
• May help address premature ejaculation^{1, 3}
• Flexible dosing options for varied lifestyles

Adverse Effects

• Nausea^8-11
• Flushing^8-10
• Headache^8,9,11
• Changes in heart rate^8,9,11
• Changes in blood pressure^8,9,11
• Dizziness^8,9,11
• Vision changes^8,9
• Muscle or back pain^8,9
• Uterine contraction (in postpartum women)¹¹

Serious Adverse Effects

• Hyperpigmentation¹¹
• Priapism (erection lasting longer than 4 hours)^8,9

Contraindications

• Not suitable for individuals with history of cardiovascular disease^8,9,11

Drug Interactions

• Use of nitrates such as Nitroglycerin^8,9
• Use of guanylate cyclase (GC) stimulators such as Riociguat^8,9

Handling requirements

• Keep away from children and pets

Olympus + combines oxytocin, bremelanotide, and tadalafil to support sexual wellness in men and women. Oxytocin is a natural hormone that plays a role in bonding, intimacy, and sexual arousal. When taken it can help activate areas of the brain linked to attraction and sexual interest. This may help increase feelings of connection and make it easier for the body to respond during sexual activity. Bremelanotide works mainly in the brain. It activates melanocortin 4 receptor (MC4R) that help promote sexual desire and arousal. By activating these receptors, it may help patients reach sexual excitement and support their overall experience. Tadalafil works in a different way. It helps relax blood vessels and improves blood flow to the penis. Better blood flow helps support getting and keeping an erection during sexual stimulation. Together, these ingredients work on both the brain and blood flow to help support a healthy sexual response.^1-7

IMPORTANT INFORMATION ABOUT COMPOUNDED MEDICATIONS

This medication has been compounded (custom-prepared) by a pharmacy. Compounded medications are specially prepared for individual patient needs based on a valid prescription from a prescribing healthcare practitioner and, as such, are not reviewed or approved by the U.S. Food and Drug Administration (FDA) for safety or efficacy. Compounded drugs are intended for patients whose prescriber has determined their medical needs are not met by an available FDA-approved drug. These statements have not been evaluated by the FDA.

This compounded preparation:

• Has not been approved by the FDA
• Has not undergone FDA review for safety, effectiveness, or quality
• Is prepared specifically for you based on your prescriber's order
• Individual outcomes may vary

Dosing is determined by the prescribing provider based on patient-specific factors. Always follow your healthcare provider's instructions. Compounded medications are not subject to FDA approval and lack the same safety and efficacy data as FDA-approved commercial medications. This medication should be prescribed and monitored by a licensed healthcare professional familiar with the condition being addressed and the specific applications of the medication.

IMPORTANT INFORMATION ABOUT COMPOUNDED MEDICATIONS
This medication has been compounded (custom-prepared) by a pharmacy.
This compounded preparation:
- Has not been approved by the FDA
- Has not undergone FDA review for safety, effectiveness, or quality
- Is prepared specifically for you based on your prescriber's order
- Individual outcomes may vary
Compounded medications are not subject to FDA approval and lack the same safety and efficacy data as FDA-approved commercial medications.
This medication should be prescribed and monitored by a licensed healthcare professional familiar with the condition being addressed and the specific applications of the medication.

1. Melis MR, Argiolas A. Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances. Int J Mol Sci. 2021 Sep
   26;22(19):10376. doi: 10.3390/ijms221910376. PMID: 34638719; PMCID: PMC8509000.
2. Oti T, Sakamoto H. Neuropeptidergic control circuits in the spinal cord for male sexual behaviour: Oxytocin-gastrin-releasing peptide systems. J
   Neuroendocrinol. 2023 Sep;35(9):e13324. doi: 10.1111/jne.13324. Epub 2023 Jul 29. PMID: 37515539.
3. Diamond LE, Earle DC, Rosen RC, Willett MS, Molinoff PB. Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic
   properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild- to-
   moderate erectile dysfunction. Int J Impot Res. 2004 Feb;16(1):51-9. doi: 10.1038/sj.ijir.3901139. PMID: 14963471.
4. Kingsberg SA, Clayton AH, Portman D, Williams LA, Krop J, Jordan R, Lucas J, Simon JA. Bremelanotide for the Treatment of Hypoactive Sexual
   Desire Disorder: Two Randomized Phase 3 Trials. Obstet Gynecol. 2019 Nov;134(5):899-908. doi: 10.1097/AOG.0000000000003500. PMID:
   31599840; PMCID: PMC6819021.
5. Caruso S, Cicero C, Romano M, Lo Presti L, Ventura B, Malandrino C. Tadalafil 5 mg daily treatment for type 1 diabetic premenopausal women
   affected by sexual genital arousal disorder. J Sex Med. 2012 Aug;9(8):2057-65. doi: 10.1111/j.1743-6109.2012.02777.x. Epub 2012 May 21. PMID:
   22612985.
6. Coward RM, Carson CC. Tadalafil in the treatment of erectile dysfunction. Ther Clin Risk Manag. 2008 Dec;4(6):1315-30. doi: 10.2147/tcrm. s3336.
   PMID: 19337438; PMCID: PMC2643112.
7. Mayer D, Lynch SE. Bremelanotide: New Drug Approved for Treating Hypoactive Sexual Desire Disorder. Ann Pharmacother. 2020 Jul;54(7):684-
   690. doi: 10.1177/1060028019899152. Epub 2020 Jan 1. PMID: 31893927.
8. Lexicomp Online. Tadalafil: Drug Information. Wolters Kluwer. Accessed March 28, 2025. Available from: https://online.lexi.com
9. Tadalafil. Prescribing information. DailyMed. National Library of Medicine. Revised October 10, 2025. Accessed February 26, 2026
10. Oxytocin. Prescribing information. DailyMed. National Library of Medicine. Revised January 12, 2025. Accessed February 26, 2026
11. Bremelanotide. Prescribing information. DailyMed. National Library of Medicine. Revised November 13, 2025. Accessed February 26, 2026
12. Adcirca (Tadalafil) [product labeling]. Indianapolis, IN, USA: Eli Lilly and Company, September 2020.
13. VYLEESI [package insert]. Bridgewater, NJ: Cosette Pharmaceuticals, Inc.; 2024.

Q: How long does it take to see a response? 

A: Typical onset has been observed within 30 minutes after taking. If no effect is seen, you may need to increase your dose up to a max of 1 full tablet per 24 hours as recommended by your prescriber.

Q: Can I use this with other medications? 

A: It can be used with other medications, but it should not be used with Nitroglycerin or other blood pressure lowering agents as it may cause a severe decrease in blood pressure. Always consult your prescribing healthcare provider before combining with other medications.

Q: What if I miss a dose? 

A: This medication is designed to be used as needed 30 minutes prior to sexual activity. There is no need to take it as a daily dosing unless needed directed by your prescriber.

Q: Why cant patients take Olympus+ with Nitrates?

A: The use of Tadalafil (PDE5i) with nitrates is contraindicated due to the risk of hypotension. Current prescribing information for tadalafil state at least 48 hours must elapse after tadalafil administration and use of an organic nitrate.¹² Nitrates relax smooth muscle causing vasodilation by stimulating cGMP production. PDE5i cause vasodilation by inhibiting an enzyme responsible for the metabolism of cGMP. The synergistic effect on cGMP is believed to be responsible for the effects on blood pressure.

Q: Why does bremelanotide cause hyperpigmentation in patients using it for sexual dysfunction?

A:Bremelanotide activates melanocortin receptors that are located in the brain and melanocytes located in the skin. The activation of melanocytes in the skin will increase melanin production and cause darkened patches of skin or gums in some patients. This hyperpigmentation is typically seen on the face, and gums the risk is higher in people with darker skin tones. In some cases, the discoloration may not fully resolve after stopping the medication, so patients are advised to stay within labeled dosing limits and to contact their clinician if they notice new or worsening dark spots while using bremelanotide.¹³