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Hormone Therapy

Capsule

RX ONLY

Kyzatrex

*
  • ACTIVE INGREDIENTS

  • HOW TO USE

    Suggested Dosing:

    Take 1 (200 mg capsule) by mouth two times per day. OR Take 2 (200 mg capsules = 400mg) by mouth two times per day.


    Dosing and Administration Characteristics of Different TRTs


    Kyzatrex

    Injection

    Pellets

    Gel

    Patches

    Oral/Easy to Swallow

    Invisible

    No Mess

    Painless

    Flexible Dosing


    *Testosterone dosing should be tailored to each patient based on individual lab values and guided by the prescriber’s clinical expertise. This approach ensures that treatment is both safe and effective, addressing the unique needs and physiological responses of each patient.

  • DISCLAIMER

    This compounded medication is only available when the commercially available product is unavailable or when a prescriber determines that there is a clinically significant difference for the patient.

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Medicine Information

  • Potential Benefits

    • Increased energy
    • Increased sex drive
    • Increased bone density 
    • Weight loss
    • Increased muscle mass
    • Better sleep
    • Decreased anxiety
  • Treatment Protocol

  • Legal

  • Storage Instructions

  • Warnings

    Important Safety Information for KYZATREX:

    KYZATREX is a controlled substance (CIII) because it contains testosterone. It is not known if KYZATREX is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children. KYZATREX is not meant for use by women.


    KYZATREX can increase blood pressure, which can increase the risk of having a heart attack or stroke and can increase risk of death due to a heart attack or stroke. Your risk may be greater if you have already had a heart attack or stroke or if you have other risk factors for heart attack or stroke.


    Important safety information continued:

    • If your blood pressure increases while on KYZATREX, blood pressure medicines may need to be started. If you are currently taking blood pressure medicines, they may need to be changed or new blood pressure medicines may need to be added to control your blood pressure.
    • If your blood pressure cannot be controlled, KYZATREX may need to be stopped.
    • Your healthcare provider will monitor your blood pressure while you are being treated with KYZATREX. Do not take KYZATREX if you: have breast cancer; have or might have prostate cancer; are a woman who is pregnant (KYZATREX may harm your unborn baby); are allergic to KYZATREX or any of its ingredients; or have low testosterone without certain medical conditions (e.g., do not take KYZATREX if you have low testosterone due to age). Before you take KYZATREX, tell your healthcare provider about all of your medical conditions, including if you: have high blood pressure or are treated for high blood pressure; have a history of diabetes; have heart problems; have high red blood cell count (hematocrit) or high hemoglobin laboratory value; have urinary problems due to an enlarged prostate; have liver or kidney problems; or have problems breathing while you sleep (sleep apnea). Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking KYZATREX with certain other medicines can cause adverse effects. Especially, tell your healthcare provider if you take: insulin; medicines that decrease blood clotting (blood thinners); corticosteroids; or medicines that increase blood pressure, such as some cold medicines and pain medicines.


    KYZATREX may cause other serious side effects, including:

    • Increase in red blood cell count (hematocrit) or hemoglobin, which can increase the risk of blood clots, strokes, and heart attacks. You may need to stop KYZATREX if your red blood cell count increases.
    • If you already have an enlarged prostate, your signs and symptoms may worsen while taking KYZATREX. These may include: increased urination at night; trouble starting your urine stream; urinating many times during the day; urge to go to the bathroom right away; a urine accident; inability to pass urine or weak urine flow.
    • Increased risk of prostate cancer.
    • Blood clots in the legs or lungs. Signs and symptoms of a blood clot in your leg can include pain, swelling or redness. Signs and symptoms of a blood clot in your lungs can include difficulty breathing or chest pain.
    • Abuse. Testosterone can be abused when taken at higher than-prescribed doses and when used with other anabolic androgenic steroids. Abuse can cause serious heart and psychological side effects.
    • In large doses, KYZATREX may lower your sperm count.
    • Liver problems. Symptoms of liver problems may include: nausea or vomiting; yellowing of your skin or whites of your eyes; dark urine; pain on the right side of your stomach area (abdominal pain).
    • Swelling of your ankles, feet, or body (edema), with or without heart failure.
    • Enlarged or painful breasts.
    • Breathing problems while you sleep (sleep apnea). Call your healthcare provider right away if you have any of the serious side effects listed above. The most common side effect of KYZATREX is high blood pressure. Other side effects may include: headache, joint or back pain, diarrhea, increased red blood cell count, anxiety, constipation, swelling of the legs, and increased prostate specific antigen (PSA) levels. These are not all the possible side effects of KYZATREX. For more information, ask your healthcare provider or pharmacist. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to Marius by visiting www.mariuspharma.com. Keep KYZATREX and all medicines out of the reach of children. See Full Prescribing Information and Medication Guide for KYZATREX. Reference: 1.  Data on file. Raleigh, NC: Marius Pharmaceuticals, 2020. 
  • Manufacturer Info

  • How It Works

    Testosterone replacement therapy (TRT) is a treatment to replace the testosterone that’s been lost and get testosterone levels back to a normal range. TRT has traditionally consisted of testosterone patches, gels, pellets, and injections. Kyzatrex® is here to change that.

    Kyzatrex® oral capsules are formulated to be easily absorbed and bypass your liver. That means it works efficiently, without causing liver damage. Kyzatrex® should be taken with food. Absorption is not affected by alcohol consumption and not materially affected by fat content.

  • F.A.Q

  • References

    1. Bernstein JS, Dhingra OP. A phase III, single-arm, 6-month trial of a wide-dose range oral testosterone undecanoate product. Ther Adv Urol. 2024 Apr 10;16:17562872241241864. doi: 10.1177/17562872241241864. PMID: 38606384; PMCID: PMC11008350.
    2. Lincoff AM, Bhasin S, Flevaris P, et al. Cardiovascular Safety of Testosterone-Replacement Therapy. N Engl J Med. 2023; 389:107-117. DOI: 10.1056/NEJMoa2215025
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