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Enclomiphene Capsule
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Enclomiphene is a Selective Estrogen Receptor Modulator (SERM), which antagonizes the effect of estrogen in the hypothalamus-pituitary-gonadal axis in males to increase testosterone. It is the active isomer of clomiphene responsible for its desirable pharmacological effects while minimizing estrogenic side effects.
ACTIVE INGREDIENTS
Enclomiphene Citrate
- Selective Estrogen Receptor Modulator (SERM)
- 100% enclomiphene (trans-isomer of clomiphene)
HOW TO USE
Usual dose
Take 1 capsule by mouth one time daily. Your provider may recommend cycling 5 days on and 2 days off, or taking every other day.
DISCLAIMER
This compounded medication is only available when the commercially available product is unavailable or when a prescriber determines that there is a clinically significant difference for the patient.
Medicine Information
Potential Benefits
Increase endogenous systemic and intratesticular testosterone in hypogonadal men. Testosterone may support improved muscle mass and strength, libido, energy level and mood and cognition.
- Associated with fewer estrogen-related side effects, such as mood changes, gynecomastia, and fluid retention, compared to clomiphene.
- Helps preserve sperm count and fertility in men with reproductive goals.
- Unlike exogenous testosterone, enclomiphene is less likely to cause testicular atrophy.
Treament Protocol
Legal
Storage Instructions
Warnings
Potential Side Effects
- Headache and nausea
- Nausea
- Visual disturbances (blurring)
- Estrogenic side effects such as gynecomastia, bloating or mood swings (lesser risk with enclomiphene as compared to clomiphene)
Manufacturer Info
How It Works
Enclomiphene is a selective estrogen receptor modulator (SERM). It is an isomer of clomiphene primarily responsible for desired pharmacological effects, whereas zuclomiphene is the isomer responsible for side effects. Enclomiphene antagonizes estrogen in the hypothalamic-pituitary-gonadal axis to induce Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). LH stimulates the Leydig cells to produce testosterone. The resulting high intratesticular testosterone supports spermatogeneis. FSH works synergistically with LH, acting on the Sertoli cells of the testes and play a role in spermatogenesis, sperm maturation, and sperm quality.
F.A.Q
References
- Wiehle R, Cunningham GR, Pitteloud N, Wike J, Hsu K, Fontenot GK, Rosner M, Dwyer A, Podolski J. Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics. BJU Int. 2013 Jul 12;112(8):1188–200. doi: 10.1111/ bju.12363. Epub ahead of print. PMID: 23875626; PMCID: PMC4155868.
- Saffati G, Kassab J, Rendon DO, Hinojosa-Gonzalez DE, Kronstedt S, Lipshultz LI, et al. MP47-02 ENCLOMIPHENE VS. CLOMIPHENE: SAFETY AND TESTOSTERONE LEVELS IN HYPOGONADAL MEN. Journal of Urology [Internet]. 2024 May 1 [cited 2025 Feb 18];211(5S):e762. Available from: https:// doi.org/10.1097/01.JU.0001008880.11564.10.02
